In 1933, Waters appeared in a satirical all-black film, Rufus Jones for President, which featured the child performer Sammy Davis Jr. as Rufus Jones. She went on to star at the Cotton Club, where, according to her autobiography, she "sang 'Stormy Weather' from the depths of the private hell in which I was being crushed and suffocated." In 1933, she had a featured role in the successful Irving Berlin Broadway musical revue As Thousands Cheer with Clifton Webb, Marilyn Miller, and Helen Broderick.
She became the first black woman to integrate Broadway's theater district, often referred to at the time as the Great White Way, more than a decade after actor Charles Gilpin's critically acclaimed performances in the plays of Eugene O'Neill beginning with The Emperor Jones in 1920.
Waters held three jobs: in As Thousands Cheer, as a singer for Jack Denny & His Orchestra on a national radio program,[8] and in nightclubs. She became the highest-paid performer on Broadway.[18] Despite this status, she had difficulty finding work. She moved to Los Angeles to appear in the 1942 film Cairo. During the same year, she reprised her starring stage role as Petunia in the all-black film musical Cabin in the Sky directed by Vincente Minnelli, and starring Lena Horne as the ingenue. Conflicts arose when Minnelli swapped songs from the original script between Waters and Horne:[19] Waters wanted to perform "Honey in the Honeycomb" as a ballad, but Horne wanted to dance to it. Horne broke her ankle and the songs were reversed. She got the ballad and Waters the dance. Waters did sing the Academy Award nominated "Happiness is Just a Thing Called Joe".[19]
In 1939 Waters became the first African American to star in her own television show before Nat King Cole appeared in 1956. The Ethel Waters Show, a 15-minute variety special, appeared on NBC on June 14, 1939; it included a dramatic performance of the Broadway play Mamba's Daughters based in the Gullah community of South Carolina and produced with her in mind. The play was based on a book of the same name by DuBose Heyward.
Waters in 1957
She was nominated for an Academy Award for Best Supporting Actress for the film Pinky (1949) under the direction of Elia Kazan after the first director, John Ford, quit over disagreements with Waters. According to producer Darryl F. Zanuck, Ford "hated that old...woman (Waters)." Ford, Kazan stated, "didn't know how to reach Ethel Waters." Kazan later referred to Waters's "truly odd combination of old-time religiosity and free-flowing hatred."
In 1950, she won the New York Drama Critics Circle Award for her performance opposite Julie Harris in the play The Member of the Wedding. Waters and Harris repeated their roles in the 1952 film version. In 1950, Waters was the first African American actress to star in the television series Beulah. It was first nationally broadcast weekly television series starring an African-American in the leading role appearing on ABC television from 1950 to 1953. She quit, after complaining that the portrayal of blacks was "degrading", and was replaced by Louise Beavers in its third season. She guest-starred in 1957 and 1959 on NBC's The Ford Show, Starring Tennessee Ernie Ford. In a 1957 episode, she sang "Cabin in the Sky".[25] Her appearance in a 1961 episode of Route 66 received a 1962 Primetime Emmy Award nomination, the first dramatic performance by a black performer so recognized (male or female), as well as the first black woman nominated for an Emmy.
She lost tens of thousands in jewelry and cash in a robbery, and she had difficulties with the Internal Revenue Service. Her health suffered, and she worked sporadically in the following years. In 1950–51 she wrote her autobiography, His Eye Is on the Sparrow, with Charles Samuels in which she wrote candidly about her life. She explained why her age had often been misstated: her friends had to sign a paper claiming Waters was four years younger than she was to get a group insurance deal; she stated that she was born in 1900. His Eye Is on the Sparrow was adapted for a stage production in which she was portrayed by Ernestine Jackson. In her second autobiography, To Me, It's Wonderful, Waters stated that she was born in 1896.